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Associate Professor Cellular and Structural Biology -
Principal Investigator Greehey Children's Cancer Research Institute

Member of the Cancer Therapy and Research Center - Link
Member of the Barshop Institute for Longevity and Aging Studies - Link
Programmatic Member of Molecular Medicine - Link


Alex Bishop, D.Phil., joined the Greehey Children’s Cancer Research Institute in September of 2004 with major faculty responsibilities as a Principal Investigator in Molecular Oncogenesis. He is also an Associate Professor in the Department of Cellular and Structural Biology and a member of both the Cancer Therapy and Research Center (a NCI-designated cancer center). He received his doctoral degree from Oxford University and completed two post-doctoral fellowships at Harvard University.


Dr. Bishop is a molecular geneticist whose research focuses on DNA damage responses and the resultant genomic instability, a fundamental cause of cancer. His laboratory is involved in two major lines of research, discovering new genes and pathways involved in damage survival and understanding how damage survival genes affect maintenance of genomic integrity via the homologous recombination process. The goal is to apply the knowledge gained to the treatment of cancer. This work has several important applications, including improving our understanding of the basic biology of cellular processes, providing insights into cancer etiology and progression and identifying prognostics for cancer treatment as well as developing novel treatment strategies.


Recent Publications:
Lee et al. Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. Science 2012 Apr; 336(6078): 225-228


Zimmer et al. Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative disease Experimental Hematology 2012 Apr; 40(4): 295-306

Lin et al. Journal of Biological Chemistry 2011 Dec; 286(51): 44023-44034

Brown et al. Developing a conditional mouse model for measuring the effect of essential genes on the frequency of homologous recombination events in vivo. Molecular and Cellular Biology 2011; 31(17):3593-602


Honors & Awards:
2010 Cellular and Structural Biology Award for Excellence in
Graduate Student Education
: Award for teaching contributions to
the Department.
2010 Voelcker Fund Young Investigator Award
2009 NCI Travel Award: Award to attend and present at the 3rd US-EU
workshop Systems Biology of the DNA Damage Response
2004 K22 Transitions to Independent Positions: Fellowship from NIEHS
2002 Keystone Scholarship: Scholarship to Replication and
Recombination Conference
2001 Keystone Scholarship: Scholarship to Molecular Basis of Cancer
1999 ASM Travel Grant: Award to attend ASM DNA repair meeting
1999 Keystone Scholarship: Scholarship to attend Molecular Basis of
Cancer Conference
1997 F32 Postdoctoral Fellowship: Fellowship from NIGMS (NIH)
1997 ACS Postdoctoral Fellowship (not accepted due to F32 Fellowship
1993 MRC (UK) Graduate Student Fellowship: Fellowship for PhD
Professional Affiliations:

2011 - Present           Academic Editor PLoS ONE
2011 - Present           Associate Member of the Children’s Oncology Group
2010 - Present           American Association for Cancer Research (116260)
2010 - Present           Environmental Mutagen Society
2005 - Present           Mbr. of the Nathan Shock Aging Center & Barshop Inst.
2005 - Present           Member of Cancer Therapy and Research Institute
2000 - Present           American Society for Microbiology (554456533)
1995 - 1997               UK Genetical Society 



NIH NCI: 1R01CA152063-01A1        LINK Period: 09/2011 - 07/2016
NIH NIEHS: 1R15ES019128-01 LINK Period: 04/2010 - 03/2013
Voelcker Fund Young
Investigator Award  
LINK Period: 07/2010 - 06/2013
USAMRAC (Student fellowship
to Karia): BC093931
LINK Period: 01/2010 - 12/2012
NIH NIA (Student fellowship to Brown): 5T32AG021890 LINK Period: 05/2008 - 04/2013
Greehey Graduate Fellowship Award (Student fellowship to Gorthi): BC093931 LINK Period: 09/2011 - 08/2012
Helen Freeborn Kerr Charitable Foundation Award     Period: 09/2011 - 04/2012
GCCRI Ambassador’s Circle Research Support Award     Period: 02/2012 - 01/2013


NIH NIEHS: K22ES12264     LINK Period: 09/2004 - 05/2010
CTRC: 128253   Period: 12/2008 - 04/2010
Nathan Shock Institute: 121295   Period: 07/2005 - 06/2006
American Cancer Society: 122295   Period: 08/2005 - 08/2006



Dr. Bishop takes an active part in teaching at UTHCSA, is director of Cancer Biology Core I and Module co-director for the Advanced Cell and Molecular Biology course amongst other teaching responsibilities.


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