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| Don McEwen , Ph. D. |
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Principal Investigator, Assistant Professor of Biochemistry
T 210.562.9064 |
Donald G. McEwen, Ph.D., will join the Children’s Cancer Research Institute in February of 2005 with major faculty responsibilities as a Principal Investigator in Molecular Oncogenesis and Assistant Professor in the Department of Biochemistry. Dr. McEwen received his doctoral degree from Washington University and completed his post-doctoral fellowship at the University of North Carolina, Lineberger Comprehensive Cancer Center. His post-doctoral work in the laboratory of Dr. Mark Peifer has been supported by a fellowship from the University of North Carolina Lineberger Comprehensive Cancer Center and by a National Research Service Award from NIGMS, NIH.
Dr. McEwen is a developmental biologist who is taking a genetic and biochemical approach to the analysis of signaling pathways involved in development, differentiation, and cancer. He is utilizing Drosophila as a powerful model system to study the effects of WNT and JNK signaling pathways.
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Select Publications |
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Reinhold , M. I., McEwen, D.G., Ornitz , D. M., and Michael C. Naski. (2004) Fibroblast Growth Factor Receptor 3 Gene: Regulation by Serum Response Factor. Molecular Endocrinology 18:241-251 |
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Wang, Q., McEwen, D. G. and D.M. Ornitz (2000) Subcellular and developmental expression of alternatively spliced formsof fibroblast growth factor 14. Mech Dev 90 :283-7. |
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McCartney, B.M., McEwen, D. G. , Grevengoed, E., Maddox, P., Bejsovec, A., and M. Peifer. (2001) Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin. Nature Cell Biology ,3: 933-8. |
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McEwen, D. G. and D.M. Ornitz (1997) Regulation of the fibroblast growth factor receptor 3 promoter and intron I enhancer by Sp1 family transcription factors. J. Biol. Chem. 273 : 5349-5357 |
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Cox, R. T., McEwen, D. G. , Myster, D. L., Duronio, R. J., Loureiro, J., and M. Peifer. (2000) A screen for mutations that suppress the phenotype of Drosophila armadillo , the beta-catenin homolog. Genetics 155 :1725-40. |
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McEwen, D. G. and D.M. Ornitz (1997) Determination of FGFR expression in mouse, rat, and human samples using a single primer pair. BioTechniques 22 : 1068-1070 |
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McEwen, D. G., Cox, R.T., and M. A. Peifer (2000) The canonical Wg and JNK signaling cascades collaborate to promote both dorsal closure and ventral patterning. Development 127 :3607-17. |
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Ornitz, D.M., Xu, J., Colvin, J.S., McEwen, D. G. , MacArthur, C.A., Coulier, F., Gao, G. and M. Goldfarb (1996) Receptor Specificity of the fibroblast growth factor family. J. Biol. Chem. 271 : 15292-15297. |
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