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| Vivienne I. Rebel, M.D., Ph. D. |
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Principal Investigator, Assistant Professor of Cellular and Structural Biology
T 210.562.9096
rebel@uthscsa.edu
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Vivienne Rebel joined the Greehey Children’s Cancer Research Institute in November of 2005 with major faculty responsibilities as a Principal Investigator in Hematologic Malignancies and Assistant Professor in the Department of Cellular and Structural Biology. She received her medical degree at the Free University in Amsterdam, The Netherlands. She completed her doctoral degree from Free University and the Terry Fox Laboratory in Vancouver, Canada. She completed a post-doctoral fellowship at Harvard Medical School at the Dana-Farber Cancer Institute, where she received the David Abraham Fellowship. She is currently an Instructor in the Department of Pediatrics at Harvard Medical School and the Department of Cancer Biology at the Dana-Farber Cancer Institute.
Dr. Rebel’s research focuses on elucidating the molecular mechanisms that govern stem cell regulation in vivo. Knowledge about stem cell regulation may also benefit our understanding of cancer cell development
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| Select Publications |
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Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, Akashi K, and Sicinski P. "Mouse development and cell proliferation in the absence of D-cyclins." Cell 2004;118:477-491. |
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*Kung AL, *Rebel VI, Bronson RT, Ch’ng L-E, Sieff CA, Livingston DM, * Yao T-P. "Gene dose-dependent control of hematopoietic differentiation and hematologic tumor suppression by CBP." Genes Dev 2000;14:272-277.
* equal authors |
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*Rebel VI , *Kung AL, Tanner, EA, Yang, H, Bronson, RT, and Livingston DM. "Distinct roles for CREB-binding protein (CBP) and p300 in hematopoietic stem cell self-renewal." Proc. Natl. Acad. Sci. USA 2002;99:14789-14794.
* equal authors |
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Hill GR, Teshima T, Rebel VI, Krijanovski OI, Cooke KR, Brinson YS, Ferrara JLM. "The p55 TNF-x receptor plays a critical role in T cell alloreactivity." J Immunol 2000;164:656-663. |
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Layne MD, Patel A, Chen Y-H, Rebel VI, Carvajal IM, Pellacani A, Ith B, Zhao D, Schreiber BM, Yet S-F, Lee M-E, Storch J, and Perrella MA. "Role of macrophage-expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice." FASEB J 2001;15:2733-2735. |
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Rebel VI , Hartnett S, Hill G, Lazo-Kallanian SB, Ferrara JLM, Sieff CA. "Essential role for the p55 tumor necrosis factor receptor in regulating hematopoiesis at a stem cell level." J Exp Medicine 1999;190:1493-1503. |
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Friedman JS, Rebel VI, Derby R, Bell K, Huang T-T, Kuypers FA, Epstein CJ, Burakoff SJ. "Absence of mitochondrial superoxide dismutase results in a murine hemolytic anemia responsive to therapy with a catalytic antioxidant." J Exp Medicine 2001;193:925-934.
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Rebel VI , Tanaka M, Lee J-S, Hartnett S, Pulsipher M, Nathan DG, Mulligan RC, Sieff CA. "One-day ex vivo culture allows effective gene transfer into human nonobese diabetic/severe combined immune-deficient repopulating cells using high-titer vesicular stomatitis virus G protein pseudotyped retrovirus." Blood 1999;93:2217-2224. |
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Rebel VI , Hartnett S, Denham J, Chan M, Finberg R, Sieff CA. "Maturation and lineage-specific expression of the coxsakie and adenovirus receptor in hematopoietic cells." Stem Cells 2000;18:176-182. |
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Miller CL, Rebel VI, Helgason CD, Lansdorp PM, Eaves CJ. "Impaired steel factor responsiveness differentially affects the detection and long-term maintenance of fetal liver hematopoietic stem cells in vivo." Blood 1997;89:1214-1223. |
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