Degeng Wang, PhD - Associate Professor in the Division of Bioinformatics of the Department of Epidemiology & Biostatistics
Dr. Wang joined the Greehey Children’s Cancer Research Institute in August of 2011 as a Principal Investigator in functional genomics and an Associate Professor in the Division of Bioinformatics of the Department of Epidemiology & Biostatistics. The Wang lab combines computational, genomic, and molecular and cellular approaches to tackle fundamental mechanisms, through which cancer cells break free from normal regulation.
The lab focuses on understanding the operations of cellular biochemical networks and their aberrancy in cancers, with a current emphasis on cancer metabolism. Cellular proteins do not act alone. They form – either by themselves or together with other cellular molecules – biochemical pathways, functional domains, and ultimately a network. Through gene expression regulation and post-translational modification, the cells dynamically control these pathways in response to signals or to carry out specific functions. Oncogenic mutations can usually be associated with specific pathways, for instance, the wnt-catenin-TCF signaling pathway. In case of metabolism, the glycolysis pathway and the TCA cycle are frequent targets of genetic alterations in many cancers. We strive to improve our understanding of the functional impact of these genetic alterations at the systems biology level and, ultimately, provide biomedical insight for therapy improvement.