
At the Greehey Children’s Cancer Research Institute, faculty members continue to achieve new advancements within their research. Below is a list of publications that have been published for this year.
Bansal, H, Seifert, T, Bachier, C, Rao, MK, Tomlinson, GE, Padmanabhan, S and Bansal, S. 2012. The transcription factor Wilms tumor 1 confers resistance in myeloid leukemia cells against the proapoptotic therapeutic protein TRAIL by regulating the antiapoptotic protein Bcl-xL, J. Biol Chem, Sept 287(39) 32875-80.
PMID: 22898820.
Hsu FH, Serpedin E, Hsiao TH, Bishop AJ, Dougherty ER, Chen Y.
Reducing confounding and suppression effects in TCGA data: an integrated analysis of chemotherapy response in ovarian cancer. BMC Genomics. 2012;13 Suppl 6:S13. doi: 10.1186/1471-2164-13-S6-S13. Epub 2012 Oct 26.PMID:23134756
Doderer MS, Anguiano Z, Suresh U, Dashnamoorthy R, Bishop AJ, Chen Y.
Pathway Distiller - multisource biological pathway consolidation. BMC Genomics. 2012;13 Suppl 6:S18. doi: 10.1186/1471-2164-13-S6-S18. Epub 2012 Oct 26. PMID: 23134636
Ravi D, Bishop AJ. Identification of genes required for damage survival using a cell-based RNAi screen against the Drosophila genome. Methods Mol Biol. 2012;920:9-26. doi: 10.1007/978-1-61779-998-3_2. PMID: 22941593
Kim TM, Ko JH, Hu L, Kim SA, Bishop AJ, Vijg J, Montagna C, Hasty P.
RAD51 mutants cause replication defects and chromosomal instability.
Mol Cell Biol. 2012 Sep;32(18):3663-80. doi: 10.1128/MCB.00406-12. Epub 2012 Jul 9. PMID: 22778135
Lee IH, Cao L, Kawai Y, Fergusson MM, Liu J, Rovira I, Bishop AJR, Motoyama N, Komatsu M and Finkel T. Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. Science 2012 Apr; 336(6078): 225-228. PMID: 22499945
Zimmer SN, Lemieux ME, Karia BP, Day C, Zhou T, Zhou Q, Kung AL, Suresh U, Chen Y, Kinney MC, Bishop AJ, Rebel VI. Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm. Exp Hematol. 2012 Apr;40(4):295-306.e5. Epub 2011 Dec 20. PMID: 22198154
Hsu FH, Serpedin E, Hsiao TH, Bishop AJR, Dougherty ER, Chen Y. Integrative Genomic Identification of Genes on 8p Associated With Hepatocellular Carcinoma Progression and Patient Survival. Genomic Signal Processing and Statistics (GENSIPS), 2011 IEEE International Workshop, 4-6 Dec. 2011. March 15, 2012. Page 46, E-ISBN: 978-1-4673-0489-4 Print ISBN: 978-1-4673-0491-7
Doderer M, Anguiano Z, Suresh U, Dashnamoorthy R, Bishop AJR, Chen Y. Multisource Biological Pathway Consolidation, submitted to Special Issue of BMC Genomics, Feb 2012.
Kim TM, Ko JH, Hu L, Kim SA, Bishop AJ, Vijg J, Montagna C, Hasty P. RAD51 Mutants Cause Replication Defects and Chromosomal Instability. Mol Cell Biol. 2012 Sept.; 32(18): 3663-80. Jul 9 Epub.PMID:22778135
Ravi D, Bishop AJ. Identification of Genes Required for Damage Survival Using a Cell-Based RNAi Screen Against the Drosophila Genome. Methods Mol Cell Biol. 920:9-26 PMID: 22941593
Hsu FH, Serpedin E, Hsiao TH, Bishop AJ, Dougherty ER, Chen Y.
Reducing confounding and suppression effects in TCGA data: an integrated analysis of chemotherapy response in ovarian cancer. BMC Genomics. 2012;13 Suppl 6:S13. doi: 10.1186/1471-2164-13-S6-S13. Epub 2012 Oct 26.
PMID: 23134756
Doderer MS, Anguiano Z, Suresh U, Dashnamoorthy R, Bishop AJ, Chen Y.
Pathway Distiller - multisource biological pathway consolidation. BMC Genomics. 2012;13 Suppl 6:S18. doi: 10.1186/1471-2164-13-S6-S18. Epub 2012 Oct 26. PMID: 23134636
Pal R, Huang Y, Chen Y. Selected articles from the IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS'2011).
BMC Genomics. 2012;13 Suppl 6:S1. doi: 10.1186/1471-2164-13-S6-S1. Epub 2012 Oct 26. PMID: 23134705
Hsu FH, Serpedin E, Chen Y, Dougherty ER. Evaluating dynamic effects of copy number alterations on gene expression using a single transcription model.
IEEE Trans Biomed Eng. 2012 Oct;59(10):2726-36. PMID: 22996722
Panneerdoss S, Chang YF, Buddavarapu KC, Chen HI, Shetty G, Wang H, Chen Y, Kumar TR, Rao MK. Androgen-responsive microRNAs in mouse Sertoli cells. PLoS One. 2012;7(7):e41146. doi: 10.1371/journal.pone.0041146. Epub 2012 Jul 20. PMID: 22911753
Zimmer SN, Lemieux ME, Karia BP, Day C, Zhou T, Zhou Q, Kung AL, Suresh U, Chen Y, Kinney MC, Bishop AJ, Rebel VI. Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm. Exp Hematol. 2012 Apr; 40(4):295-306.e5. Epub 2011 Dec 20. PMID: 22198154
Xiao Y, Hsiao TH, Suresh U, Chen HI, Wu X, Wolf SE, Chen Y. A Novel Significance Score for Gene Selection and Ranking. Bioinformatics. 2012 Feb 9. [Epub ahead of print] PMID: 22321699
Roessler S, Ezhou , Budhu A, Chen Y, Zhao X, Ji J, Walker R, Jia HL, Ye QH, Qin LX, Tang ZY, He P, Hunter KW, Thorgeirsson SS, Meltzer PS, Wang XW, et al. Integrative Genomic Identification of Genes on 8p Associated With Hepatocellular Carcinoma Progression and Patient Survival. Gastroenterology. 2012 Apr; 142(4):957-966.e12. Epub 2011 Dec 24. PMID: 22202459 PMCID: PMC3321110
Killian JK, Walker RL, Bilke S, Chen Y, Davis S, Cornelison R, Smith WI, Meltzer PS. Genome-wide methylation profiling in archival formalin-fixed paraffin-embedded tissue samples, Methods Mol Biol. 2012; 823:107-18. PMID: 22081342
Zhang W, Greene W, Gao SJ. Microtubule- and dynein-dependent nuclear trafficking of rhesus rhadinovirus in rhesus fibroblasts. J Virol. 2012 Jan; 86(1):599-604. Epub 2011 Oct 26 PMID: 22031929 PMCID: PMC3255885
Jones T, Ye F, Bedolla R, Huang Y, Meng J, Qian L, Pan H, Zhou F, Moody R, Wagner B, Arar M, Gao SJ. Direct and efficient cellular transformation of primary rat mesenchymal precursor cells by KSHV. J Clin Invest. 2012 Mar 1;122(3):1076-81. doi: 10.1172/JCI58530. Feb 1. PMID: 22293176 PMCID: PMC3287217
Bai Z, Zhou F, Lei X, Ma X, Lu C, Gao SJ. A cluster of transcripts encoded by KSHV ORF30-33 gene locus. Virus Genes. 2012 Apr;44(2):225-36. Epub 2011 Dec 17. PMID: 22180077 PMCID: PMC3290719
Greene W, Zhang W, He M, Witt C, Ye F, Gao SJ. The ubiquitin/proteasome system mediates entry and endosomal trafficking of Kaposi’s sarcoma associated heprpesvirus in endothelial cells. PLoS Pathog. 2012 May; 8(5): e1002703. Epub 2012 May 17
Lai Z, Kane NC, Kozik A, Hodgins KA,Dlugosch KM, Barker MS,atvienko M,Yu Q, Turner KG, Pearl SA, Bell GD, Zou Y, Grassa C, Guggisberg A, Adams KL,Anderson JVHorvath DP, Kesseli RV,>Burke JM,Michelmore RW, Rieseberg LH. Source ; Department of Biology and Center for Genomics and Bioinformatics, Indiana University, Bloomington, Indiana 47405 USA. PMID: 2205818
Gowda PS,Zhou F, Chadwell LV, McEwen DG. p53 binding prevents phosphatase-mediated inactivation of diphosphorylated JUN N-terminal kinase.Source UTHSCSA, United States. J Biol Chem. 2012 May; 287(21): 17554-67 Epub Mar 30. PMID: 22467874
Lan R, Geng H, Polichnowski AJ, Singha PK, Saikumar P, McEwen DG, Griffin KA, Koesters R,Weinberg JM, Bidani AK, Kriz W, Venkatachalam MA. PTEN loss defines a TGF-β-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis. Am J Physiol Renal Physiol. 2012 May; 302(9):F1210-23. Epub 2012 Feb 1.PMID: 2230162
Robinson AK, Leal BZ, Chadwell LV, Wang R, Ilangovan U, Kaur Y, Junco SE, Schirf V, Osmulski PA, Gaczynska M, Hinck AP, Demeler B, McEwen DG, Kim CA. The growth-suppressive function of the Polycomb group protein Polyhomeotic is mediated by polymerization of its sterile alpha motif (SAM) domain. J Biol Chem. 2012 Mar; 287(12): 8702-13 Epub Jan 24.PMID: 22275371
Uren PJ, Bahrami-Samani E, Burns SC, Qiao M, Karginov FV, Hodges E, Hannon GJ, Sanford JR, Penalva LO, Smith AD. Site identification in high-throughput RNA-protein interaction data. Bioinformatics. 2012 Dec 1;28(23):3013-20. doi: 10.1093/bioinformatics/bts569. Epub 2012 Sep 28. PMID: 230324010
Vo DT, Subramaniam D, Remke M, Burton TL, Uren PJ, Gelfond JA, de Sousa Abreu R, Burns SC, Qiao M, Suresh U, Korshunov A, Dubuc AM, Northcott PA, Smith AD, Pfister SM, Taylor MD, Janga SC, Anant S, Vogel C, Penalva LO.
The RNA-binding protein Musashi1 affects medulloblastoma growth via a network of cancer-related genes and is an indicator of poor prognosis. Am J Pathol. 2012 Nov;181(5):1762-72. doi: 10.1016/j.ajpath.2012.07.031. Epub 2012 Sep 14. PMID: 22985791
Araujo PR, Yoon K, Ko D, Smith AD, Qiao M, Suresh U, Burns SC, Penalva LO. Before It Gets Started: Regulating Translation at the 5' UTR. Comp Funct Genomics. 2012;2012:475731. doi: 10.1155/2012/475731. Epub 2012 May 28. PMID: 22693426
Glazer RI, Vo DT, Penalva LO. Musashi1: an RBP with versatile functions in normal and cancer stem cells. Front Biosci. 2012 Jan 1; 17:54-64.
PMID: 22201732
Vo DT, Abdelmohsen K, Martindale JL, Qiao M, Tominaga K, Burton TL, Gelfond JA, Brenner AJ, Patel V, Trageser D, Scheffler B, Gorospe M, Penalva LO. The Oncogenic RNA-Binding Protein Musashi1 Is Regulated by HuR via mRNA Translation and Stability in Glioblastoma Cells. Mol Cancer Res. 2012 Jan; 10(1):143-55.PMID: 22258704
Araju PR, Yoon K, Ko D, Smith AD, Qiao M, Suresh U, Burns SC, Penalva LO. Before It Gets started: Regulating Translation at the 5’ UTR. Comp Funct Genomics 2012:475731 Epub May 28
Vo DT, Subramaniam D, Remke M, Burton TL, Uren PJ, Gelfond JA, de Sousa Abreu R, Burns SC, Qiao M, Suresh U, Korshunov A, Dubuc AM, Northcott PA, Smith AD, Pfister SM, Taylor MD, Janga SC, Anant S, Vogel C, Penalva LO. The RNA-Binding Protein Musashi1 Affects Medulloblastoma Growth via a Network of Cancer-Related Genes and Is an Indicator of Poor Prognosis.
Am J Pathol. 2012 Sep 14. pii: S0002-9440(12)00601-3. doi:10.1016/j.ajpath.2012.07.031. [Epub ahead of print] PMID: 22985791
ENCODE Project Consortium, Bernstein BE, Birney E, Dunham I, Green ED, Gunter C, Snyder M. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012 Sep 6;489(7414):57-74. doi: 10.1038/nature11247.
PMID: 22955616 [PubMed - in process]
Du L and Pertsemlidis A. microRNA regulation of cell viability and drug sensitivity in lung cancer. Expert Opinion on Biological Therapy, Sept: 12(9): 1221-39 Epub Jun 26. PMID: 22731874
Du L, Subauste MC, DeSevo C, Borkowski R, Baker M, Schageman JJ, Greer R, Yang C, Wistuba II, Gazdar AF, Minna JD and Pertsemlidis A. microRNA 337-3p and its targets STAT3 and RAP1A modulate paclitaxel sensitivity in non-small cell lung cancer. PLoS ONE, 2012: 7(6):e39167 Epub June 18 PMID:22723956
Ahn YH, Gibbons DL, Chakravarti D, Creighton CJ, Rizvi ZH, Adams HP, Pertsemlidis A, Gregory PA, Wright JA, Goodall GJ, Flores ER, Kurie JM. ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression. J Clin Invest. 2012 Sep 4;122(9):3170-83. doi: 10.1172/JCI63608. Epub 2012 Aug 1. PMID: 22850877
Imam JS, Plyler JR, Bansal H, Prajapati S, Bansal S, Rebeles J, Chen HI, Chang YF, Panneerdoss S, Zoghi B, Buddavarapu KC, Broaddus R, Hornsby P, Tomlinson G, Dome J, Vadlamudi RK, Pertsemlidis A, Chen Y, Rao MK.
Genomic Loss of Tumor Suppressor miRNA-204 Promotes Cancer Cell Migration and Invasion by Activating AKT/mTOR/Rac1 Signaling and Actin Reorganization.
PLoS One. 2012;7(12):e52397. doi: 10.1371/journal.pone.0052397. Epub 2012 Dec 21. PMID: 23285024
Chang YF, Lee-Chang JS, Imam JS, Buddavarapu KC, Subaran SS, Sinha-Hikim AP, Gorospe M, Rao MK. Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation. Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):5750-5. Epub 2012 Mar 23. PMID: 22447776
Bansal, H, Seifert, T, Bachier, C, Rao, MK, Tomlinson, GE, Padmanabhan, S and Bansal, S. 2012. The transcription factor Wilms tumor 1 confers resistance in myeloid leukemia cells against the proapoptotic therapeutic protein TRAIL by regulating the antiapoptotic protein Bcl-xL, J. Biol Chem, Sept 287(39) 32875-80.
PMID: 22898820.
Panneerdoss S, Chang YF, Buddavarapu KC, Chen HI, Shetty G, Wang H, Chen Y, Kumar TR, Rao MK. Androgen-Responsive MicroRNAs in Mouse Sertoli Cells. PLoS One. 2012;7(7):e41146. Epub 2012 Jul 20. PMID:
22911753
LM Scott, VI Rebel. JAK2 and genomic instability in the myeloproliferative neoplasms: a case of the chicken or the egg? Am J Hematol. Epub 2012 Apr 26, 2012. doi: 10.1002/ajh.23243.
SN Zimmer, ME. Lemieux, BP Karia, C Day, T Zhou, Q Zhou, AL Kung, U Suresh, Y Chen, MC Kinney, AJR Bishop, VI Rebel. Mice heterozygous for CREB binding protein are hypersensitive to g-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm. Exp Hematol. 2012; 40:295-306.e5. Epub 2011 Dec 20.
Shim JH, Greenblatt MB, Singh A, Brady N, Hu D, Drapp R, Ogawa W, Kasuga M, Noda T, Yang SH, Lee SK, Rebel VI, Glimcher LH. Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice. J Clin Invest.2012 Jan 3;122(1):91-106. doi: 10.1172/JCI59466. Epub 2011 Dec 1. PMID: 22133875
Harris SE, Macdougall M, Horn D, Woodruff K, Zimmer SN, Rebel VI, Fajardo R, Feng JQ, Gluhak-Heinrich J, Harris MA, Abboud Werner S. Meox2Cre-mediated disruption of CSF-1 leads to osteopetrosis and osteocyte defects.Bone. 2012 Jan;50(1):42-53. Epub 2011 Sep 20. PMID:21958845
Elzi DJ, Song M, Hakala K, Weintraub ST, Shiio Y. Wnt antagonist SFRP1 functions as a secreted mediator of senescence. Mol Cell Biol. 2012 Nov;32(21):4388-99. doi: 10.1128/MCB.06023-11. Epub 2012 Aug 27.
PMID: 2297647
Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y.The interaction of the von Hippel-Lindau tumor suppressor and heterochromatin protein 1. Arch Biochem Biophys. 2012 Feb; 518(2): 103-10 Epub Jan 3. PMID: 22234250
Elzi DJ, Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y. Plasminogen activator inhibitor 1 – insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence. Proc Natl Acad Sci USA 2012 Jul; 109(30):12052-7 Epub Jul 9 PMID: 22778398
Elzi DJ, Song M, Hakala K, Weintraub ST, Shiio Y.Wnt antagonist SFRP1 functions as secreted mediator of senescence. Mol Cell Biol. 2012 Aug 27.
PMID: 22927647
Rodriguez-Galindo C, Krailo M, Frazier L, Chintagumpala M, Amatruda J, Katzenstein H, Malogolowkin M, Spector L, Pashankar F, Meyers R, Tomlinson G; on behalf of the COG Rare Tumors Disease Committee. Children's Oncology Group's 2013 blueprint for research: Rare tumors. Pediatr Blood Cancer. 2012 Dec 19. doi: 10.1002/pbc.24428. [Epub ahead of print] PMID:23255219
Tomlinson GE. Cytogenetics of hepatoblastoma. Front Biosci (Elite Ed). 2012 Jan 1; 4:1287-92. PMID: 22201954
Lin S, Yang J, Elkahloun AG, Bandyopadhyay A, Wang L, Cornell JE, Yeh I-T, Agyin J, Tomlinson G, Sun L-Z. 2012. Attenuation TGF-b signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells. Mol Biol Cell Apr 23(8):1569-1581. PMID:22357622
Finkelman BS, Friebel TM, Friedman S, Dubitsky S, Shoretz R, Singer CF, Blum JL, Tumg N, Olopade OI, Weitzel JN, Lynch HT, Garber JE, Schildkraut J, Daly MB, Isaacs C, Pichert G, Neuhausen SL, Couch FJ, vent Veer L, Rubinstein W, Eeles R, Evans DG, Ganz PA, Tomlinson GE, Narod SA, Matloff E, Domchek S, Rebbeck TR. Breast and ovarian cancer risk and risk reduction in a prospective cohort of Jewish BRCA1/2 mutation carriers.J Clin Oncol.
2012 Apr 20; 30(12):1321-8.. PMID: 22430266 PMCID: PMC3341145
Puumala SE, Ross JA, Feusner JH, Tomlinson GE, Malogolowkin MH, Krailo MD, Spector. LG. Parental infertility, infertility treatment and hepatoblastoma: a report from the Children's Oncology Group. Hum Reprod. 2012 Jun; 27(6): 1649-59 Epub Apr 3. PMID: 22473396
Ding YC, McGuffog L, Healey S, Friedman E, Laitman Y, Shimon-Paluch S, Kaufman B, Liljegren A, Lindblom A, Olsson H, Kristoffersson U, Stenmark Askmalm M, Melin B, Domchek SM, Nathanson KL, Rebbeck TR, Jakubowska A, Lubinski J, Jaworska K, Durda K, Gronwald J, Huzarski T, Cybulski C, Byrski T, Osorio A, Ramony Cajal T, Stavropoulou AV, Benítez J, Hamann U, Rookus MA, Aalfs CM, de Lange J, Meijers-Heijboer HE, Oosterwijk JC, van Asperen CJ, Gomez-Garcia EB, Hoogerbrugge N, Jager A, van der Luijt RB, Easton DF, Peock S, Frost D, Ellis SD, Platte R, Fineberg E, Evans DG, Lalloo F, Izatt L, Eeles RA, Adlard J, Davidson R, Eccles DM, Cole T, Cook J, Brewer C, Tischkowitz M, Godwin AK, Pathak HB, Stoppa-Lyonnet D, Sinilnikova OM, Mazoyer S, Barjhoux L, Leone M, Gauthier-Villars M, Caux-Moncoutier V, de Pauw A, Hardouin A, Berthet P, Dreyfus H, Fert Ferrer S, Collonge-Rame MA, Sokolowska J, Buys SS, Daly MB, Miron A, Terry MB, Chung WK, John EM, Southey MC, Goldgar DE, Singer CF, Tea Maria MK, Gschwantler-Kaulich D, Fink-Retter A, Hansen TV, Ejlertsen B, Johannsson OT, Offit K, Sarrel K, Gaudet MM, Vijai J, Robson ME, Piedmonte M, Andrews L, Cohn DE, Demars LR, Disilvestro P, Rodriguez GC, Toland AE, Montagna M, Agata S, Imyanitov EN, Isaacs C, Janavicius R, Lazaro C, Blanco I, Ramus SJ, Sucheston LE, Karlan BY, Gross J, Ganz PA, Beattie MS, Schmutzler RK, Wappenschmidt B, Meindl A, Arnold N, Niederacher D, Preisler-Adams S, Gadzicki D, Varon-Mateeva R, Deissler H, Gehrig A, Sutter C, Kast K, Nevanlinna H, Aittomäki K, Simard J, Spurdle AB, Beesley J, Chen X, Tomlinson GE, Weitzel JN, Garber JE, Olopade FI, Rubinstein WS, Tung N, Blum JL, Narod SA, Brummel S, Gillen DL, Lindor NM, Fredericksen Z, Pankratz VS, Couch FJ, Radice P, Peterlongo P, Greene MH, Loud JT, Mai PL, Andrulis IL, Glendon G, Ozcelik H, Gerdes AM, Thomassen M, Jensen UB, Skytte AB, Caligo MA, Lee A, Chenevix-Trench G, Antoniou AC, Neuhausen SL. 2012. A non-synonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev
Aug: 21(8): 1362-1370 Epub June 26.
Tomlinson GE and Kappler R. 2012 Genetics and Epigenetics of Hepatoblastoma. Pediatric Blood and Cancer, Nov; 59(5) 785-92. Epub July 13.
Bansal, H, Seifert, T, Bachier, C, Rao, MK, Tomlinson, GE, Padmanabhan, S and Bansal, S. 2012. The transcription factor Wilms tumor 1 confers resistance in myeloid leukemia cells against the proapoptotic therapeutic protein TRAIL by regulating the antiapoptotic protein Bcl-xL, J. Biol Chem, Sept 287(39) 32875-80.
PMID: 22898820.
Sugalski A, Davis MM, Prasanna L, Saldivar V, Hung J, Tomlinson GE. 2012. Malignant Mesothelioma in a Seven-Year Child: Clinical, Histologic and Genetic Features, Pediatric Blood and Cancer, Epub Sept 7. Pediatric Blood Cancer 2013 Jan 60(1):146-8.
Padawer T, Leighty R and Wang D. Duplicate Gene Enrichment and Expression Pattern Diversification in Multicellularity. Nucleic Acid Research, 2012. Sept 1; 40(16): 7597Epub May 29 PMID:22645319