Greehey CCRI Symposium 2010

Thursday, February 25th


Registration/Name Badge Distribution/Poster Check-In
Continental Breakfast (included with registration)


SESSION I—Cancer Stem Cells in Pediatric Cancers

Emerging evidence suggests that most cancers, if not all, have their own “stem cells”. This stem-like fraction within a tumor has been shown to sustain the relentless growth of the mass; as well there is some data suggesting that these cells are relatively resistant to chemo and radiation therapy. Studies have shown that the genes and pathways involved in regulating the self-renewal nature of somatic stem cells are dysfunctional in the cancer stem cell. This session will present cutting-edge research on the cellular and molecular mechanisms controlling the stem cell nature of both normal and cancerous stem cell. Topics to be discussed in this session are stem cell-ness in pediatric cancers; lessons from somatic stem cells and embryonic cells; stem cell niches in tumors and cancer stem cell as therapeutic targets


Lunch (included with registration)


SESSION II—Micro RNAs & Pediatric Cancers:

MicroRNAs (miRNAs) are naturally occurring, short non-coding RNAs believed to
be involved in many biological processes including normal development and
adult cancer. It seems logical that miRNAs would be particularly important in

pediatric cancers as these malignancies generally involve perturbations of normaldevelopmental and differentiation processes, yet relatively little is known about the role of miRNAs in pediatric cancers. Importance of miRNA in pediatric malignancies will be presented in this session.


Featured speaker will be Nobel Laureate Alfred G. Gilman, MD, PhD, Chief Scientific Officer of the Cancer Prevention and Research Institute of Texas (CPRIT). Dr. Gilman’s talk, “The Early Days of the Cancer Prevention and Research Institute of Texas,” scheduled for 4 p.m. on Thursday, Feb. 25, will discuss CPRIT’s first seven months of operation


Poster Session & Reception

(included with registration)


Friday, February 26th


Registration/Name Badge Distribution
Continental Breakfast (included with registration)


SESSION III—Pediatric Cancer Genomics

Genomics in childhood cancer study focuses on understanding the basic molecular mechanisms of childhood cancer and translate this knowledge to the clinical practice. The genome-wide approach includes systematic and comprehensive elucidation of cancers in terms of DNA alterations, RNA/miRNA profiling and regulation, proteomic signatures, functional responses, as well as the next generation sequencing technologies.  Scientists in the world leading cancer institute, National Cancer Institute, will share ideas and discuss collaborative projects in this session.

  Short Presentations (TBA)
  Lunch(included with registration)

SESSION IV—Pediatric Cancer Population Genetics

The heterogeneity of populations explains the variation in the occurrence of cancer as well as variation in response to therapy and outcomes. Genetic factors associated with population characteristics (e.g., race, ethnicity, and sex) can be linked with susceptibility. Variation in genetic factors can include differences in single point mutations in cancer susceptibility genes, differences in SNPs, DNA copy number variations (CNVs) and other epigenetics characteristics. Detection of these population associated genetic variations can potentially identify individuals at high risk for the development of cancer, as well individuals who are most likely to benefit from a particular therapeutic approach.